动态足底触觉仪是用以自动评估啮齿类动物跖面的“触觉感应”。它与电子触觉测量(Electronic Von Frey )和足底触觉测量(Plantar Von Frey )类似,不同之处在于它能记录持续时间和爪缩回时的作用力。 可移动的触觉刺激装置放于实验动物足底,可根据实验人员需要设定力的大小和力增大的速度等.
开始: |
软键 |
可设力范围: |
0 -50.0 g, 分辨率为0.5 g |
可设力增加率: |
1 - 50 s, 分辨率为1s |
着力丝移动范围; |
12 mm |
实验时间: |
液晶屏显示,分辨率为0.1s |
连接电脑: |
DELTA 9-pin 连接线 |
电源: 规格: 动物罩子: |
85-264 VAC - 50-60Hz - 20 W max 85 x 40 x 40 cm 3个,每个20x20x14(h) cm |
净重: |
12.50 Kg. |
毛重: 包装规格: |
约21.50 Kg 98x49x47cm |
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特征 |
优点 |
仪器自动施力 |
施力速度、方向等保持一致性 |
操作人员只需按动开关 |
相比用Von Frey测试,本实验时间短,且操作人员不会感到沉闷 |
力的大小和增加量可预置 |
更多参数符合实验需要 |
提及动态足底触觉仪的文献:
- R. Lu, A. Schmidtko: “Direct Intrathecal Drug Delivery in Mice for Detecting In Vivo Effects of cGMP on Pain Processing” Methods in Molecular Biology 1020: 215-221, 2013
- I.Q. Russe et alia: “Activation of the AMP-Activated Protein Kinase Reduces Inflammatory Nociception” Journal of Pain 2, 2013
- J. Btesh et alia: “Mapping the Binding Site of TRPV1 on AKAP79: Implications for Inflammatory Hyperalgesia” J. Neuroscience 33 (21): 9184-9193, 2013
- V. Brázda et alia: “Dynamic Response to Peripheral Nerve Injury Detected by In Situ Hybridization of IL-6 and its Receptor mRNAs in the Dorsal Root Ganglia is not Strictly Correlated With Signs of Neuropathic Pain” Molecular Pain 9(42), 2013
- V. Shunmugavel et alia: “Simvastatin Ameliorates Cauda Equina Compression Injury in a Rat Model of Lumbar Spinal Stenosis” J. Neuroimmune Pharmacology 8 (1): 274-286, 2013
- O. Coste et alia: “The p21-activated kinase PAK 5 is involved in formalin-induced nociception through regulation of MAP-kinase signaling and formalin-specific receptors” Behavioural Brain Research 234 (1): 121-128, 2012
- M.K. Boettger et alia: “Differential Effects of Locally and Systemically Administered Soluble Glycoprotein 130 on Pain and Inflammation in Experimental Arthritis” Arthritis Research & Therapy 12 (R140): 1-9, 2010
- A.L.M. Scott and M.S. Ramer: ” Schwann Cell p75NTR Prevents Spontaneous Sensory Reinnervation of the Adult Spinal Cord” Brain: 1-12, 2010
- M. Rosemann et alia: “Microphthalmia, Parkinsonism, and Enhanced Nociception in Pitx3416insG Mice” Mamm Genome 21: 12-27, 2010- D. Piomelli et alia:” Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism”.Nature NSC, 2010
- L. Ramer et alia: "Rho-Kinase Inhibition Enhances Axonal plasticity and Attenuates Cold Hyperalgesia after Dorsal Rhizotomy" J. Neuroscience, 24 (48), 10796-10805, 2004
- E. Escribano et alia: "Rapid Human Skin Permeation and Topical Anaesthetic Activity of a New Amethocaine Microemulsion" Skin Pharmacol. Physiol., 18, 294-300, 2004
- G. Villetti et alia: "Antinociceptive Activity of the N-Methyl-D-aspartate Receptor Antagonist N-(2-Indanyl)-glycinamide Hydrochloride (CHF3381) in Experimental Models of Inflammatory and Neuropathic Pain" J. Pharmacol. Exper. Therap., 306, 804-814, 2003
- M. Isabel Arévalo et alia: "Thermal Hyperalgesia and Light Touch Allodynia After Intradermal Mycobacterium butyricum Administration in Rat" Inflammation, 27 (5), 293-299, 2003
Durham Holders for Orofacial Stimulation
- F.G. Garrett, P.L. Durham et alia: “Validation of a Novel Rat-Holding Device for studying heat- and mechanical-Evoked Trigeminal Nocifensive Behavioral Responses” J. Orofacial Pain, 26 (4): 336- 344,2012
- F.G. Garrett, P.L. Durham et alia: “Development of a novel device for measuring withdrawal latency by thermal stimulation in rodent facial pain models using the Hargreaves Plantar Apparatus” Poster presented at SFN 2010
Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats
Paul J. Austin, Ann Wu, Gila Moalem-Taylor
School of Medical Sciences, University of New South Wales
Due to the simplicity of surgery and the robust behavioural outcome, chronic constriction of the sciatic nerve is one of the pre-eminent animal models of neuropathic pain. Within 24 hrs following surgery, pain hypersensitivity is established and can be quantitatively measured using a von Frey aesthesiometer (mechanical test) and plantar analgesia meter (thermal test).
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