转棒实验是运动协调方面药物筛选的重要方法。根据 N.W Dunham 和 T.S Miya 1957年的论文。在1960年,Ugo Basile设计了第一个RotaRod转棒仪。
转棒实验是运动协调方面药物筛选的重要方法。根据 N.W Dunham 和 T.S Miya 1957年的论文。在1960年,Ugo Basile设计了第一个RotaRod转棒仪。
数据读取: | 液晶显示 | 数据采集: | 52050-07软件 |
转棒开始: | START (蓝色)键 | 电源: | universal input 85-264 VAC, 50-60Hz,最大40 W |
转棒停止: | RESET/STOP(红色)键 | 工作温度: | 10°- 40°C |
设置速度: | 功能键 | 声级: | < 60 dB |
速度重置: | RESET/STOP (红色)键 | 打印: | 7145微型热敏打印机(需购置) |
转子: | 直径3cm转鼓 |
物理尺寸 |
|
净重: |
11.0 Kg |
尺寸: |
46 (w) x 28 (d) x 33 (h) cm |
毛重: |
Kg 16.0 (approx.) |
包装尺寸: 转子: 走道宽度: 下落高度: |
66 x 50 x63 cm 直径3cm 5.7cm 16cm |
特征 |
优点 |
转速可调5-80RPM,每次1RPM |
予以小鼠舒适的活动环境 |
匀速,加速,多次加速模式(新) |
可用于研究运动学习机运动功能 |
可使用USB闪存盘 |
无需连接电脑即可储存数据 |
新版软件 |
新款触摸屏能够设置实验参数、管理实验数据。 |
方法文献
§ N.W. Dunham & T.S. Miya: “A Note on a Sinple Apparatus for Detecting Neurological Deficit in Rats & Mice“ J. Am. Pharmaceut. Assoc., Scientific Edit., XLVI: No. 3, 1957
§ B.J. Jones & D.J. Roberts: “The Quantitative Measurement of Motor Inco-ordination in Naive Mice Using an Accelerating Rotarod“ J. Pharm. Pharmac.: 20: 302-304, 1968
使用转棒仪技术的相关文献:
§ B.J. Turner et alia: “Overexpression of Survival Motor Neuron Improves Neuromuscular Function and Motor Neuron Survival in Mutant SOD1 Mice” Neurobiol. Of Aging 35 (4): 906-915,2014
§ M. Milanese et alia: “Knocking Down Metabotropic Glutamate Receptor 1 Improves Survival And Disease Progression in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis” Neurobiology of Disease 64: 48-59, 2014
§ J.E. Lorenz: “Oxidant-Induced Activation of cGMP-Dependent Protein Kinase Iα Mediates Neuropathic Pain After Peripheral Nerve Injury” Antioxidants & Redox Signaling Jan. 2014
§ J.N. Justice et alia: “Battery of Behavioral Tests in Mice that Models Age-Associated Changes in Human Motor Function” Age Oct 2013
§ A.S. Hamlin et alia: “Lesions of the Basal Forebrain Cholinergic System in Mice Disrupt Idiothetic Navigation” PLoS ONE 8(1): e53472, 2013
§ T. Rantamäki et alia: “The Impact of Bdnf Gene Deficiency to the Memory Impairment and Brain Pathology of APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease” PLoS ONE 8(7): e68722, 2013
§ T. Murakami et alia: “Vascular Endothelial Growth Factor Electro-Gene Therapy Improves Functional Outcome in a Mouse Model of ALS” Immunology, Endocrine & Metabolic Agents: 13 (2): 107-111, 2013
§ R. Günther et alia: “Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis (ALS)” JoVE J. Vis. Exp. (61), e3936, doi:10.3791/3936, 2012http://www.jove.com/video/3936/clinical-testing-spinal-cord-removal-mouse-model-for-amyotrophic
§ A.J. Grottick et alia: “Studies to investigate the role of 5-HT 2C Receptors on Cocaine- and Food-Maintained Behavior”: J. Pharmacol. Exper. Therap., 2000
§ L.T. Huang et alia: “Pentylenetetrazol-Induced Recurrent Seizures in Rat Pups: Time Course on Spatial Learning and Long…”: Epilepsia, 2002
§ E. Candelario-Jalil et alia: “Wide Therapeutic Time Window for Nimesulide Neuroprotection in a Model of Transient Focal Cerebral Ischemia in the Rat”: Brain Research: 177: 98-108, 2004
§ C.D. Heldermon et alia: “CliTherapeutic Efficacy of Bone Marrow Transplant, Intracranial AAV-mediated Gene Therapy, or Both in the Mouse Model of MPS IIIB” Molecular Therapy 15(5): 873-880, 2010 (rocking)
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